Bindehautdegenerationen und -neoplasien

Erhabenheiten der Bindehaut entstehen durch Gewebevermehrung, die entweder degenerativ oder neoplastisch sein können. In diesem Artikel werden degenerative (Pterygium und Pinguecula) sowie benigne und maligne neoplastische Bindehautveränderungen (epitheliale, melanozytäre und vaskuläre Tumoren, Choristome sowie Metastasen) bezüglich der Pathogenese, Symptome, Diagnostik und aktuellem Stand der Behandlung abgehandelt.

• Literatur

• 1 Al-Barrag A, Al-Shaer M, Al-Matary N et al. 5-Fluorouracil for the treatment of intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and cornea. Clin Ophthalmol 2010; 4: 801-808
• 2 Ali AM, Thariat J, Bensadoun RJ et al. The role of radiotherapy in the treatment of pterygium: a review of the literature including more than 6000 treated lesions. Cancer Radiother 2011; 15: 140-147
• 3 Al Fayez MF. Limbal-conjunctival vs conjunctival autograft transplant for recurrent pterygia: a prospective randomized controlled trial. JAMA Ophthalmol 2013; 131: 11-16
• 4 Alomar TS, Nubile M, Lowe J et al. Corneal intraepithelial neoplasia: in vivo confocal microscopic study with histopathologic correlation. Am J Ophthalmol 2011; 151: 238-247
• 5 Ang LPK, Chua JLL, Tan DTH. Current concepts and techniques in pterygium treatment. Curr Opin Ophthalmol 2007; 18: 308-313
• 6 Auw-Haedrich C, Coupland SE, Kapp A et al. Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American Lymphoma. Br J Ophthalmol 2001; 85: 63-69
• 7 Auw-Haedrich C. Bindehautmelanom. Z Prakt Augenheilkd 2006; 27: 244-250
• 8 Basti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea 2003; 22: 687-704
• 9 Beutel J, Sommer K, Gottschalk S et al. Plattenepithelkarzinom der Bindehaut mit Orbitainvasion. Ophthalmologe 2006; 103: 693-697
• 10 Blasi MA, Tiberti AC, Valente P et al. Intralesional interferon-α for conjunctival mucosa-associated lymphoid tissue lymphoma: long-term results. Ophthalmology 2012; 119: 494-500
• 11 Bock F, Regenfuss B, Cursiefen C. Antiangiogene Therapie am vorderen Augenabschnitt: Wann? Was? Wofür?. Ophthalmologe 2011; 108: 230-236
• 12 Bredow L, Martin G, Reinhard T et al. Recurrent conjunctival papilloma progressing into squamous cell carcinoma with change of HPV-finding during the course. Br J Ophthalmol 2009; 93: 1437 1451
• 13 Cartsburg O, Kersten A, Sundmacher R et al. Behandlung von 9 plattenepithelialen Carcinomata in situ der Bindehaut (CIN) mit Mitomycin-C-Augentropfen unter zytologischer und DNA-bildzytometrischer Kontrolle. Klin Monatsbl Augenheilkd 2001; 218: 429-434
• 14 Chauhan S, Sen S, Sharma A et al. Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients. Br J Ophthalmol 2012; 96: 1517-1521
• 15 Chiang CC, Cheng YW, Lin CL et al. Cyclooxygenase 2 expression in pterygium. Mol Vis 2007; 13: 635-638
• 16 Damato B, Coupland SE. An audit of conjunctival melanoma treatment in Liverpool. Eye (Lond) 2009; 23: 801-809
• 17 Damato B, Coupland SE. Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging. Clin Experiment Ophthalmol 2008; 36: 786-795
• 18 Di Girolamo N, Chui J, Coroneo MT et al. Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases. Prog Retin Eye Res 2004; 23: 195-228
• 19 Droutsas K, Sekundo W. Epidemiologie des Pterygiums. Ophthalmologe 2010; 107: 511-516
• 20 Eberwein P, Maier P, Auw-Haedrich C et al. [Isolated corneal intraepithelial dysplasia]. Ophthalmologe 2009; 106: 918-920
• 21 Feltgen N, Auw-Hädrich C. Ungewöhnlicher Bindehauttumor bei einer jungen Atopikerin. Ophthalmologe 2005; 102: 1204-1206
• 22 Font RL, Rishi K. Sebaceous gland adenoma of the tarsal conjunctiva in a patient with Muir-Torre syndrome. Ophthalmology 2003; 110: 1833-1836
• 23 Fry CL, Leone jr. CR. Safe management of dermolipomas. Arch Ophthalmol 1994; 112: 1114-1116
• 24 Goebel N, Serr A, Mittelviefhaus H et al. Chlamydia psittaci, Helicobacter pylori and ocular adnexal lymphoma-is there an association? The German experience. Leuk Res 2007; 31: 1450-1452
• 25 Heindl LM, Hofmann-Rummelt C, Adler W et al. Prognostic significance of tumor-associated lymphangiogenesis in malignant melanomas of the conjunctiva. Ophthalmology 2011; 118: 2351-2360
• 26 Herwig MC, Fischer HP, Holz FG et al. Konjunktivales Myxom – zwei Kasuistiken. Ophthalmologe 2010; 107: 843-847
• 27 Herwig MC, Wells JR, Grossniklaus HE. Conjunctival stromal tumor: report of 4 cases. Ophthalmology 2012; 119: 682-687
• 28 Hirst LW. The treatment of pterygium. Surv Ophthalmol 2003; 48: 145-180
• 29 Honavar SG, Shields CL, Maus M et al. Primary intraepithelial sebaceous gland carcinoma of the palpebral conjunctiva. Arch Ophthalmol 2001; 119: 764-767
• 30 Kallen C, Reinhard T, Schilgen G et al. Atopische Keratokonjunktivitis. Ophthalmologe 2003; 100: 808-814
• 31 Kao AA, Galor A, Karp CL et al. Clinicopathologic correlation of ocular surface squamous neoplasms at Bascom Palmer Eye Institute: 2001 to 2010. Ophthalmology 2012; 119: 1773-1776
• 32 Kass LG, Hornblass A. Sebaceous carcinoma of the ocular adnexa. Surv Ophthalmol 1989; 33: 477-490
• 33 Kirova YM, Belembaogo E, Frikha H et al. Radiotherapy in the management of epidemic Kaposiʼs sarcoma: a retrospective study of 643 cases. Radiother Oncol 1998; 46: 19-22
• 34 Kruse R, Rütten A, Lamberti C et al. Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria. Am J Hum Genet 1998; 63: 63-70
• 35 Küçükerdönmez C, Akova YA, Altinörs DD. Comparison of conjunctival autograft with amniotic membrane transplantation for pterygium surgery: surgical and cosmetic outcome. Cornea 2007; 26: 407-413
• 36 Lange CA, Tisch-Rottensteiner J, Böhringer D et al. Enhanced TKTL1 expression in malignant tumors of the ocular adnexa predicts clinical outcome. Ophthalmology 2012; 119: 1924-1929
• 37 Lapp T, Birnbaum F, Evert M et al. Kornealer Tumor nach Vorderkammerlinsenimplantation bei Marfan-Syndrom. Ophthalmologe 2012; 109: 155-160
• 38 Lapp T, Mittelviefhaus H, Werner M et al. Severe bleeding eyelid after trivial trauma: conjunctival metastasis of a renal cell carcinoma. Graefes Arch Clin Exp Ophthalmol 2012; 250: 1705-1706
• 39 Levecq L, De Potter P, Jamart J. Conjunctival nevi clinical features and therapeutic outcomes. Ophthalmology 2010; 117: 35-40
• 40 Maalouf TJ, Dolivet G, Angioi KS et al. Sentinel lymph node biopsy in patients with conjunctival and eyelid cancers: experience in 17 patients. Ophthal Plast Reconstr Surg 2012; 28: 30-34
• 41 Maxia C, Perra MT, Demurtas P et al. Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium. Mol Vis 2009; 15: 458-463
• 42 Messmer EM, Mackert MJ, Zapp DM et al. In vivo confocal microscopy of pigmented conjunctival tumors. Graefes Arch Clin Exp Ophthalmol 2006; 244: 1437-1445
• 43 Mimura T, Mori M, Obata H et al. Conjunctivochalasis: associations with pinguecula in a hospital-based study. Acta Ophthalmol 2012; 90: 773-782
• 44 Müller S, Stahn J, Schmitz K et al. Rezidivraten nach Pterygiumoperation mit Bindehautschwenklappen vs. freies autologes Transplantat. Ophthalmologe 2007; 104: 480-483
• 45 Murube J. Pterygium: its treatment with beta therapy. Ocul Surf 2009; 7: 3-9
• 46 Norn MS. Prevalence of pinguecula in Greenland and in Copenhagen, and its relation to pterygium and spheroid degeneration. Acta Ophthalmol (Copenh) 1979; 57: 96-105
• 47 Ortiz JM, Yanoff M. Epipalpebral conjunctival osseous choristoma. Br J Ophthalmol 1979; 63: 173-176
• 48 Ozanics V, Jakobiec F. Prenatal Development of the Eye and its Adnexa. Ocular Anatomy, Embryology and Teratology. Philadelphia: Harper & Row; 1982: 11-96
• 49 Peebo BB, Fagerholm P, Lagali N. In vivo confocal microscopy visualization of presumed lymph vessels in a case of corneal transplant rejection. Clin Experiment Ophthalmol 2011; 39: 832-834
• 50 Pfeiffer ML, Savar A, Esmaeli B. Sentinel lymph node biopsy for eyelid and conjunctival tumors: what have we learned in the past decade?. Ophthal Plast Reconstr Surg 2013; 29: 57-62
• 51 Pradeep TG, Gangasagara SB, Subbaramaiah GB et al. Prevalence of undiagnosed HIV infection in patients with ocular surface squamous neoplasia in a tertiary center in Karnataka, South India. Cornea 2012; 31: 1282-1284
• 52 Rundle P, Mudhar HS, Rennie I. Conjunctival intra-epithelial neoplasia occurring in young patients with asthma. Eye (Lond) 2010; 24: 1182-1185
• 53 Sa H-S, Kim HK, Shin JH et al. Dermolipoma surgery with rotational conjunctival flaps. Acta Ophthalmol 2012; 90: 86-90
• 54 Schwartz RA, Torre DP. The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol 1995; 33: 90-104
• 55 Sekundo W, Droutsas K, Cursiefen C. Operative Techniken bei chirurgischer Behandlung primärer und rezidivierender Pterygien. Ophthalmologe 2010; 107: 525-528
• 56 Shahin MM, Elbendary AM, Elwan MM. Intraoperative subconjunctival bevacizumab as an adjunctive treatment in primary pterygium: a preliminary report. Ophthalmic Surg Lasers Imaging 2012; 43: 459-466
• 57 Shields CL, Belinsky I, Romanelli-Gobbi M et al. Anterior segment optical coherence tomography of conjunctival nevus. Ophthalmology 2011; 118: 915-919
• 58 Shields CL, Demirci H, Karatza E et al. Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors. Ophthalmology 2004; 111: 1747-1754
• 59 Shields CL, Naseripour M, Shields JA et al. Topical mitomycin-C for pagetoid invasion of the conjunctiva by eyelid sebaceous gland carcinoma. Ophthalmology 2002; 109: 2129-2133
• 60 Shields JA, Demirci H, Marr BP et al. Conjunctival epithelial involvement by eyelid sebaceous carcinoma. The 2003 J. Howard Stokes lecture. Ophthal Plast Reconstr Surg 2005; 21: 92-96
• 61 Shields JA, Mashayekhi A, Kligman BE et al. Vascular tumors of the conjunctiva in 140 cases. Ophthalmology 2011; 118: 1747-1753
• 62 Srinivasan S, Dollin M, McAllum P et al. Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial. Br J Ophthalmol 2009; 93: 215-218
• 63 Torres-Gimeno A, Martínez-Costa L, Ayala G. Preoperative factors influencing success in pterygium surgery. BMC Ophthalmol 2012; 12: 38
• 64 Triay E, Bergman L, Nilsson B et al. Time trends in the incidence of conjunctival melanoma in Sweden. Br J Ophthalmol 2009; 93: 1524-1528
• 65 Viso E, Gude F, Rodríguez-Ares MT. Prevalence of pinguecula and pterygium in a general population in Spain. Eye (Lond) 2011; 25: 350-357
• 66 Walsh-Conway N, Conway RM. Plaque brachytherapy for the management of ocular surface malignancies with corneoscleral invasion. Clin Experiment Ophthalmol 2009; 37: 577-583
• 67 Westekemper H, Schallenberg M, Tomaszewski A et al. Maligne epibulbäre Tumoren: Neue Strategien in Diagnostik und Therapie. Klin Monatsbl Augenheilkd 2011; 228: 780-792
• 68 Yousef YA, Finger PT. Predictive value of the seventh edition American Joint Committee on Cancer staging system for conjunctival melanoma. Arch Ophthalmol 2012; 130: 599-606